Vazquez is formerly the Lesbian, Gay, Bisexual & Transgender Community Center's public policy and government relations director, a post she held from June 1994 through November, 2003. As the Center's Public Policy Director she developed the Center's advocacy and education work in the public sector, including Center Kids, the Center's LGBT families project; Promote the Vote, New York's largest LGBT voter registration and mobilization program; SpeakOUT! Lesbian, Gay, Bisexual & Transgender Voices for Recovery; and Causes in Common, an organizing project to create alliances between reproductive rights and lgbt liberation activists. She oversaw the Center's government relations and public funding work and was a founding member of the steering committee for the New York State Lesbian & Gay Health and Human Services Network the Network), a Pride Agenda statewide advocacy coalition she has been instrumental in developing since 1994. To date, the Network has secured more than $12 million in state funding to meet the health and human service needs of LGBT people throughout the state.

Born in the hills of Puerto Rico and tempered in New York City's black Harlem projects, Vazquez returned to New York City after living and working in the San Francisco Bay Area for 19 years. She served as coordinator of Lesbian & Gay Health Services for the S.F. Department of Public Health from 1988 through 1994, and was the founding director of the S.F. Women's Building. She has also worked with a host of other organizations including Community United Against Violence; the San Francisco Human Rights Commission; Somos Hermanas (a Central American Women's Solidarity Network); the National Network for Immigrant and Refugee Rights; the Lesbian Agenda for Action; and the Lavender Youth Recreation and Information Center. She served on the board of directors for the National Gay and Lesbian Task Force from 1990 through 1993. In 1998, she completed a 4-year term of service with the board of directors of the OUT Fund for Lesbian and Gay Liberation, a project of the Funding Exchange. Vazquez currently serves on the board of directors for the Center for Lesbian & Gay Studies/City University of New York, and on the national advisory boards for the National Center for Lesbian Rights and GenderPAC.

Vazquez has had her speeches and essays published in several anthologies.

She lives in Brooklyn, N.Y., with partner Carlie Steen.